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Exon First Nucleotide Mutations in Splicing: Evaluation of In Silico Prediction Tools
Mutations in the first nucleotide of exons (E(+1)) mostly affect pre-mRNA splicing when found in AG-dependent 3′ splice sites, whereas AG-independent splice sites are more resistant. The AG-dependency, however, may be difficult to assess just from primary sequence data as it depends on the quality o...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931810/ https://ncbi.nlm.nih.gov/pubmed/24586880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089570 |
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