Serum and Glucocorticoid-Inducible Kinase1 Increases Plasma Membrane wt-CFTR in Human Airway Epithelial Cells by Inhibiting Its Endocytic Retrieval

BACKGROUND: Chloride (Cl) secretion by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) located in the apical membrane of respiratory epithelial cells plays a critical role in maintenance of the airway surface liquid and mucociliary clearance of pathogens. Previously, we and others hav...

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Detalhes bibliográficos
Main Authors: Bomberger, Jennifer M., Coutermarsh, Bonita A., Barnaby, Roxanna L., Sato, J. Denry, Chapline, M. Christine, Stanton, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931797/
https://ncbi.nlm.nih.gov/pubmed/24586903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089599
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