Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants.

To examine microbiological ring expansion of penicillin N to a cephalosporin, we obtained five mutants of Cephalosporium acremonium blocked in beta-lactam antibiotic biosynthesis from 2500 survivors of mutagenesis. In submerged fermentation, mutants M-0198, M-0199, and M-2351 produced no beta-lactam...

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Detalhes bibliográficos
Main Authors: Yoshida, M, Konomi, T, Kohsaka, M, Baldwin, J E, Herchen, S, Singh, P, Hunt, N A, Demain, A L
Formato: Artigo
Idioma:Inglês
Publicado em: 1978
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC393159/
https://ncbi.nlm.nih.gov/pubmed/282643
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