Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. The reduce...

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Main Authors: Cui, Xiaobin, Zhao, Zhimin, Liu, Dong, Guo, Tao, Li, Su, Hu, Jianming, Liu, Chunxia, Yang, Lan, Cao, Yuwen, Jiang, Jinfang, Liang, Weihua, Liu, Wei, Li, Shugang, Wang, Lianghai, Wang, Lidong, Gu, Wenyi, Wu, Chuanyue, Chen, Yunzhao, Li, Feng
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931274/
https://ncbi.nlm.nih.gov/pubmed/24528540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-33-20
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