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Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo
OBJECTIVE: Nicotine, the main addictive ingredient in tobacco, is metabolically inactivated to cotinine primarily by the hepatic enzyme CYP2A6. Substantial genetic variation in the CYP2A6 gene results in large variation in the rates of nicotine metabolism which in turn alters smoking behaviours (e.g...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931261/ https://ncbi.nlm.nih.gov/pubmed/24305170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000026 |
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