A Cellular Model of Amyloid Precursor Protein Processing and Amyloid-β Peptide Production

BACKGROUND: A hallmark pathologic feature of Alzheimer’s disease (AD) is accumulation of neuritic senile plaques in the brain parenchyma. Neurotoxic plaque cores are composed predominantly of amyloid-β (Aβ) peptides of 40 and 42 amino acids in length, formed by sequential cleavage of amyloid precurs...

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Bibliographische Detailangaben
Hauptverfasser: Macias, MiMi P., Gonzales, Amanda M., Siniard, Ashley L., Walker, Aaron W., Corneveaux, Jason J., Huentelman, Matthew J., Sabbagh, Marwan N., Decourt, Boris
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931259/
https://ncbi.nlm.nih.gov/pubmed/24333289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2013.11.024
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