A Positive Cooperativity Binding Model between Ly49 Natural Killer Cell Receptors and the Viral Immunoevasin m157: KINETIC AND THERMODYNAMIC STUDIES

Natural killer (NK) cells discriminate between healthy and virally infected or transformed cells using diverse surface receptors that are both activating and inhibitory. Among them, the homodimeric Ly49 NK receptors, which can adopt two distinct conformations (backfolded and extended), are of partic...

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Detalhes bibliográficos
Main Authors: Romasanta, Pablo N., Curto, Lucrecia M., Urtasun, Nicolas, Sarratea, María B., Chiappini, Santiago, Miranda, María V., Delfino, José M., Mariuzza, Roy A., Fernández, Marisa M., Malchiodi, Emilio L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931067/
https://ncbi.nlm.nih.gov/pubmed/24379405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532929
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