AMP-activated Protein Kinase α2 and E2F1 Transcription Factor Mediate Doxorubicin-induced Cytotoxicity by Forming a Positive Signal Loop in Mouse Embryonic Fibroblasts and Non-carcinoma Cells

Doxorubicin is one of the most widely used anti-cancer drugs, but its clinical application is compromised by severe adverse effects in different organs including cardiotoxicity. In the present study we explored mechanisms of doxorubicin-induced cytotoxicity by revealing a novel role for the AMP-acti...

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Détails bibliographiques
Auteurs principaux: Yang, Wookyeom, Park, In-Ja, Yun, Hee, Im, Dong-Uk, Ock, Sangmi, Kim, Jaetaek, Seo, Seon-Mi, Shin, Ha-Yeon, Viollet, Benoit, Kang, Insug, Choe, Wonchae, Kim, Sung-Soo, Ha, Joohun
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931046/
https://ncbi.nlm.nih.gov/pubmed/24398673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496315
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