Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage

The clinical application of doxorubicin, one of the most effective anticancer drugs, has been limited due to its adverse effects, including cardiotoxicity. One of the hallmarks of doxorubicin-induced cytotoxicity is mitochondrial dysfunction. Despite intensive research over recent decades, there are...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Exp Mol Med
Prif Awduron: Yang, Goowon, Song, Minhyeok, Hoang, Dang Hieu, Tran, Quynh Hoa, Choe, Wonchae, Kang, Insug, Kim, Sung Soo, Ha, Joohun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080573/
https://ncbi.nlm.nih.gov/pubmed/33339952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-00541-3
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