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Photocleavable Dimerizer for the Rapid Reversal of Molecular Trap Antagonists

Herein, we report the development of a photocleavable analog of AP20187, a cell-permeable molecule used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. We demonstrate that this reagent pe...

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Hlavní autoři: Ahmed, Shubbir, Xie, Jun, Horne, David, Williams, John C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931014/
https://ncbi.nlm.nih.gov/pubmed/24421317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.513622
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