Acute and Chronic Mu Opioids Differentially Regulate Thrombospondins 1 and 2 Isoforms in Astrocytes

[Image: see text] Chronic opioids induce synaptic plasticity, a major neuronal adaptation. Astrocyte activation in synaptogenesis may play a critical role in opioid tolerance, withdrawal, and dependence. Thrombospondins 1 and 2 (TSP1/2) are astrocyte-secreted matricellular glycoproteins that promote...

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Bibliografiske detaljer
Main Authors: Phamduong, Ellen, Rathore, Maanjot K., Crews, Nicholas R., D’Angelo, Alexander S., Leinweber, Andrew L., Kappera, Pranay, Krenning, Thomas M., Rendell, Victoria R., Belcheva, Mariana M., Coscia, Carmine J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930990/
https://ncbi.nlm.nih.gov/pubmed/24304333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400172n
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