Proteinase-Activated Receptor-1, CCL2, and CCL7 Regulate Acute Neutrophilic Lung Inflammation

PAR(1) plays a central role in mediating the interplay between coagulation and inflammation, but its role in regulating acute neutrophilic inflammation is unknown. We report that antagonism of PAR(1) was highly effective at reducing acute neutrophil accumulation in a mouse model of LPS-induced lung...

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Detalhes bibliográficos
Main Authors: Mercer, Paul F., Williams, Andrew E., Scotton, Christopher J., José, Ricardo J., Sulikowski, Michal, Moffatt, James D., Murray, Lynne A., Chambers, Rachel C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930934/
https://ncbi.nlm.nih.gov/pubmed/23972264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0142OC
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