Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth

BACKGROUND: Recent genome-wide studies have shown that approximately 30% of diffuse large B-cell lymphoma (DLBCL) cases harbor mutations in the histone acetyltransferase (HAT) coactivators p300 or CBP. The majority of these mutations reduce or eliminate the catalytic HAT activity. We previously demo...

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Autori principali: Haery, Leila, Lugo-Picó, Julián G, Henry, Ryan A, Andrews, Andrew J, Gilmore, Thomas D
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930761/
https://ncbi.nlm.nih.gov/pubmed/24529102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-29
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