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Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment

Progranulin (PGRN) is a highly unusual molecule with both neuronal and microglial expression with two seemingly unrelated functions, i.e., as a neuronal growth factor and a modulator of neuroinflammation. Haploinsufficiency due to loss of function mutations lead to a fatal presenile dementing illnes...

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Bibliografske podrobnosti
Main Authors: Suh, Hyeon-Sook, Gelman, Benjamin B., Lee, Sunhee C.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930627/
https://ncbi.nlm.nih.gov/pubmed/23959579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-013-9495-z
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