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Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment
Progranulin (PGRN) is a highly unusual molecule with both neuronal and microglial expression with two seemingly unrelated functions, i.e., as a neuronal growth factor and a modulator of neuroinflammation. Haploinsufficiency due to loss of function mutations lead to a fatal presenile dementing illnes...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930627/ https://ncbi.nlm.nih.gov/pubmed/23959579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-013-9495-z |
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