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Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain

JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a disease that occurs primarily in people who are immunocompromised and is usually fatal. As with other Polyomavirus family members, the replicatio...

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Detalhes bibliográficos
Main Authors: Meinke, Gretchen, Phelan, Paul J., Kalekar, Radha, Shin, Jong, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930596/
https://ncbi.nlm.nih.gov/pubmed/24586168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003966
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