k-OptForce: Integrating Kinetics with Flux Balance Analysis for Strain Design

Computational strain design protocols aim at the system-wide identification of intervention strategies for the enhanced production of biochemicals in microorganisms. Existing approaches relying solely on stoichiometry and rudimentary constraint-based regulation overlook the effects of metabolite con...

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Autores principales: Chowdhury, Anupam, Zomorrodi, Ali R., Maranas, Costas D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930495/
https://ncbi.nlm.nih.gov/pubmed/24586136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003487
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