Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load. Mutations in genes encoding proteins of the inner nuclear membrane and nucleoskeleton, which cause cardiomyopathy, also disru...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Banerjee, Indroneal, Zhang, Jianlin, Moore-Morris, Thomas, Pfeiffer, Emily, Buchholz, Kyle S., Liu, Ao, Ouyang, Kunfu, Stroud, Matthew J., Gerace, Larry, Evans, Sylvia M., McCulloch, Andrew, Chen, Ju
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930490/
https://ncbi.nlm.nih.gov/pubmed/24586179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004114
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky