The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines

Wnt/β-catenin is a major regulator of stem cell self-renewal and differentiation and this signaling pathway is aberrantly activated in a several cancers, including osteosarcoma (OS). Attenuation of Wnt/β-catenin activity by tankyrase inhibitors is an appealing strategy in treatment of OS. The effica...

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Bibliografiske detaljer
Main Authors: Wessel Stratford, Eva, Daffinrud, Jeanette, Munthe, Else, Castro, Russell, Waaler, Jo, Krauss, Stefan, Myklebost, Ola
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons Ltd. 2014
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930388/
https://ncbi.nlm.nih.gov/pubmed/24403055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.170
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