A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling

Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) muta...

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Bibliographic Details
Main Authors: Cauwe, Bénédicte, Tian, Lei, Franckaert, Dean, Pierson, Wim, Staats, Kim A, Schlenner, Susan M, Liston, Adrian
Format: Artigo
Language:Inglês
Published: John Wiley & Sons Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930376/
https://ncbi.nlm.nih.gov/pubmed/24164480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12199
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