Cholesterol is a critical cellular component for T-lymphocyte cytotoxicity.

Preincubation of cytolytic T lymphocytes (CTLs) generated in secondary C57BL/6 anti-DBA/2 mixed leukocyte cultures with an inhibitor of cellular cholesterol synthesis (25-OH-cholesterol) for 24 hr strongly depressed the cytolytic activity as determined in a 3-hr 51Cr assay. The effect of the inhibit...

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Bibliographic Details
Main Authors: Heiniger, H J, Brunner, K T, Cerottini, J C
Format: Artigo
Language:Inglês
Published: 1978
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC393032/
https://ncbi.nlm.nih.gov/pubmed/310124
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