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Cholesterol is a critical cellular component for T-lymphocyte cytotoxicity.
Preincubation of cytolytic T lymphocytes (CTLs) generated in secondary C57BL/6 anti-DBA/2 mixed leukocyte cultures with an inhibitor of cellular cholesterol synthesis (25-OH-cholesterol) for 24 hr strongly depressed the cytolytic activity as determined in a 3-hr 51Cr assay. The effect of the inhibit...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1978
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393032/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/310124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.11.5683 |
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