KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model

BACKGROUND: The treatment of metastatic colorectal cancer (mCRC) includes drugs targeting the epidermal growth factor receptor (EGFR). Mutation in codon 12 or 13 in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene, downstream of the EGFR, evokes constitutive activation of the RAS/RAF/MAPK...

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Bibliographic Details
Main Authors: Kumar, Shalini Sree, Price, Timothy J., Mohyieldin, Omar, Borg, Matthew, Townsend, Amanda, Hardingham, Jennifer E.
Format: Artigo
Language:Inglês
Published: International Society of Gastrointestinal Oncology 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930148/
https://ncbi.nlm.nih.gov/pubmed/24558511
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