KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model

BACKGROUND: The treatment of metastatic colorectal cancer (mCRC) includes drugs targeting the epidermal growth factor receptor (EGFR). Mutation in codon 12 or 13 in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene, downstream of the EGFR, evokes constitutive activation of the RAS/RAF/MAPK...

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Detaylı Bibliyografya
Asıl Yazarlar: Kumar, Shalini Sree, Price, Timothy J., Mohyieldin, Omar, Borg, Matthew, Townsend, Amanda, Hardingham, Jennifer E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Society of Gastrointestinal Oncology 2014
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930148/
https://ncbi.nlm.nih.gov/pubmed/24558511
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