Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells. Such cells display enhanced resistance to standard chemotherapeutic agents and repopulate tumours after therapy. He...

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Hauptverfasser: Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929804/
https://ncbi.nlm.nih.gov/pubmed/24548894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4295
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