IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling

Interferon regulatory factor 8 (IRF8) is known to affect the innate immune response, for example, by regulating the differentiation and function of immune cells. However, whether IRF8 can influence cardiac hypertrophy is unknown. Here we show that IRF8 levels are decreased in human dilated/hypertrop...

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Detalhes bibliográficos
Main Authors: Jiang, Ding-Sheng, Wei, Xiang, Zhang, Xiao-Fei, Liu, Yu, Zhang, Yan, Chen, Ke, Gao, Lu, Zhou, Heng, Zhu, Xue-Hai, Liu, Peter P., Bond Lau, Wayne, Ma, Xinliang, Zou, Yunzeng, Zhang, Xiao-Dong, Fan, Guo-Chang, Li, Hongliang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929801/
https://ncbi.nlm.nih.gov/pubmed/24526256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4303
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