Tristetraprolin Mediates Anti-Inflammatory Effect of Carbon Monoxide against DSS-Induced Colitis

Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. Howeve...

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Autors principals: Joe, Yeonsoo, Uddin, Md. Jamal, Zheng, Min, Kim, Hyo Jeong, Chen, Yingqing, Yoon, Nal Ae, Cho, Gyeong Jae, Park, Jeong Woo, Chung, Hun Taeg
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929600/
https://ncbi.nlm.nih.gov/pubmed/24586391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088776
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