An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins

Multi-transmembrane proteins are especially difficult targets for antibody generation largely due to the challenge of producing a protein that maintains its native conformation in the absence of a stabilizing membrane. Here, we describe an immunization strategy that successfully resulted in the iden...

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Detalhes bibliográficos
Main Authors: Hazen, Meredith, Bhakta, Sunil, Vij, Rajesh, Randle, Steven, Kallop, Dara, Chiang, Vicki, Hötzel, Isidro, Jaiswal, Bijay S, Ervin, Karen E, Li, Bing, Weimer, Robby M, Polakis, Paul, Scheller, Richard H, Junutula, Jagath R, Hongo, Jo-Anne S
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929459/
https://ncbi.nlm.nih.gov/pubmed/24121517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26761
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