A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer

Placental alkaline phosphatase (PLAP) is a promising ovarian cancer biomarker. Here, we describe the isolation, affinity-maturation and characterization of two fully human monoclonal antibodies (termed B10 and D9) able to bind to human PLAP with a dissociation constant (K(d)) of 10 and 30 nM, respec...

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Bibliographic Details
Main Authors: Ravenni, Niccolò, Weber, Marcel, Neri, Dario
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929458/
https://ncbi.nlm.nih.gov/pubmed/24247025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27230
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