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Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects

The functional dichotomy of antibodies against interleukin-2 (IL-2) is thought to depend upon recognition of different cytokine epitopes. Beyond functional studies, the only molecular evidence obtained so far located the epitopes recognized by the immunoenhancing antibodies S4B6 and JES6–5H4 within...

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Detalhes bibliográficos
Main Authors: Rojas, Gertrudis, Cabrera Infante, Yanelys, Pupo, Amaury, Carmenate, Tania
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929449/
https://ncbi.nlm.nih.gov/pubmed/24253188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27224
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