Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue.

Glucocerebrosidase was purified 26,000-fold from spleens from normal humans and from patients with Gaucher disease (Gaucher spleens). The specific activities of the purified normal and mutant enzymes with glucocerebroside as substrate were 8.5 X 10(5) and 5.4 X 10(4) nmol/mg of protein per hr, respe...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pentchev, P G, Brady, R O, Blair, H E, Britton, D E, Sorrell, S H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1978
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/29293/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.8.3970
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