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Thermodynamic and Structural Basis for Relaxation of Specificity in Protein-DNA Recognition
As a novel approach to the structural and functional properties that give rise to extremely stringent sequence specificity in protein-DNA interactions, we have exploited “promiscuous” mutants of EcoRI endonuclease to study the detailed mechanism by which changes in a protein can relax specificity. T...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928799/ https://ncbi.nlm.nih.gov/pubmed/24041571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.09.005 |
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