Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncerta...

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المؤلفون الرئيسيون: Peloso, Gina M., Auer, Paul L., Bis, Joshua C., Voorman, Arend, Morrison, Alanna C., Stitziel, Nathan O., Brody, Jennifer A., Khetarpal, Sumeet A., Crosby, Jacy R., Fornage, Myriam, Isaacs, Aaron, Jakobsdottir, Johanna, Feitosa, Mary F., Davies, Gail, Huffman, Jennifer E., Manichaikul, Ani, Davis, Brian, Lohman, Kurt, Joon, Aron Y., Smith, Albert V., Grove, Megan L., Zanoni, Paolo, Redon, Valeska, Demissie, Serkalem, Lawson, Kim, Peters, Ulrike, Carlson, Christopher, Jackson, Rebecca D., Ryckman, Kelli K., Mackey, Rachel H., Robinson, Jennifer G., Siscovick, David S., Schreiner, Pamela J., Mychaleckyj, Josyf C., Pankow, James S., Hofman, Albert, Uitterlinden, Andre G., Harris, Tamara B., Taylor, Kent D., Stafford, Jeanette M., Reynolds, Lindsay M., Marioni, Riccardo E., Dehghan, Abbas, Franco, Oscar H., Patel, Aniruddh P., Lu, Yingchang, Hindy, George, Gottesman, Omri, Bottinger, Erwin P., Melander, Olle, Orho-Melander, Marju, Loos, Ruth J.F., Duga, Stefano, Merlini, Piera Angelica, Farrall, Martin, Goel, Anuj, Asselta, Rosanna, Girelli, Domenico, Martinelli, Nicola, Shah, Svati H., Kraus, William E., Li, Mingyao, Rader, Daniel J., Reilly, Muredach P., McPherson, Ruth, Watkins, Hugh, Ardissino, Diego, Zhang, Qunyuan, Wang, Judy, Tsai, Michael Y., Taylor, Herman A., Correa, Adolfo, Griswold, Michael E., Lange, Leslie A., Starr, John M., Rudan, Igor, Eiriksdottir, Gudny, Launer, Lenore J., Ordovas, Jose M., Levy, Daniel, Chen, Y.-D. Ida, Reiner, Alexander P., Hayward, Caroline, Polasek, Ozren, Deary, Ian J., Borecki, Ingrid B., Liu, Yongmei, Gudnason, Vilmundur, Wilson, James G., van Duijn, Cornelia M., Kooperberg, Charles, Rich, Stephen S., Psaty, Bruce M., Rotter, Jerome I., O’Donnell, Christopher J., Rice, Kenneth, Boerwinkle, Eric, Kathiresan, Sekar, Cupples, L. Adrienne
التنسيق: Artigo
اللغة:Inglês
منشور في: Elsevier 2014
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928662/
https://ncbi.nlm.nih.gov/pubmed/24507774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.01.009
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