Insulin downregulates the expression of the Ca(2+)-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models

We recently proposed that the transient receptor potential melastatin 5 (TRPM5) cation channel contributes to glucose-induced electrical activity of the β cell and positively influences glucose-induced insulin release and glucose homeostasis. In this study, we investigated Trpm5 expression and funct...

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Hlavní autoři: Colsoul, Barbara, Jacobs, Griet, Philippaert, Koenraad, Owsianik, Grzegorz, Segal, Andrei, Nilius, Bernd, Voets, Thomas, Schuit, Frans, Vennekens, Rudi
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2013
Témata:
Signaling and Cell Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928505/
https://ncbi.nlm.nih.gov/pubmed/24221356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-013-1389-7
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