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Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors
[Image: see text] The molecular mechanisms by which different proteins assemble into highly ordered fibrillar deposits and cause disease remain topics of debate. Human amylin (also known as islet amyloid polypeptide/hIAPP) is found in vivo as amyloid deposits in the pancreatic islets of sufferers of...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2013
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928500/ https://ncbi.nlm.nih.gov/pubmed/24372466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja406831n |
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