Insulin resistance due to a defect distal to the insulin receptor: Demonstration in a patient with leprechaunism

We have studied a 2-year-old girl with acanthosis nigricans, glucose intolerance, marked hyperinsulinemia, and somatic features characteristic of the leprechaunism syndrome. Circulating plasma insulin levels were increased up to 50-fold and the patient showed a blunted hypoglycemic response to an in...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Kobayashi, Masashi, Olefsky, Jerrold M., Elders, Joycelyn, Mako, Mary E., Given, Bruce D., Schedwie, Heinrich K., Fiser, Robert H., Hintz, Raymond L., Horner, James A., Rubenstein, Arthur H.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1978
Teme:	Biological Sciences: Medical Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392799/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/277948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.7.3469
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