HO-1 Induction by CO-RM2 Attenuates TNF-α-Induced Cytosolic Phospholipase A(2) Expression via Inhibition of PKCα-Dependent NADPH Oxidase/ROS and NF-κB

Rheumatoid arthritis (RA) is characterized by chronic inflammatory infiltration of the synovium and elevation of proinflammatory cytokines. Cytosolic phospholipase A(2) (cPLA(2)) is involved in the development of inflammatory diseases. Heme oxygenase-1 (HO-1) has been shown to possess anti-inflammat...

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Hlavní autoři: Chi, Pei-Ling, Liu, Chun-Ju, Lee, I-Ta, Chen, Yu-Wen, Hsiao, Li-Der, Yang, Chuen-Mao
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927740/
https://ncbi.nlm.nih.gov/pubmed/24616552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/279171
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