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Diminishing return for increased Mappability with longer sequencing reads: implications of the k-mer distributions in the human genome
BACKGROUND: The amount of non-unique sequence (non-singletons) in a genome directly affects the difficulty of read alignment to a reference assembly for high throughput-sequencing data. Although a longer read is more likely to be uniquely mapped to the reference genome, a quantitative analysis of th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927684/ https://ncbi.nlm.nih.gov/pubmed/24386976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-2 |
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