miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. In this study, we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knoc...

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Detalhes bibliográficos
Main Authors: Forloni, Matteo, Dogra, Shaillay Kumar, Dong, Yuying, Conte, Darryl, Ou, Jianhong, Zhu, Lihua Julie, Deng, April, Mahalingam, Meera, Green, Michael R, Wajapeyee, Narendra
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927633/
https://ncbi.nlm.nih.gov/pubmed/24550252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01460
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