Role of nucleotides in tubulin polymerization: effect of guanosine 5'-methylene diphosphonate.

Incubation of purified rat brain tubulin with guanosine 5'-methylene diphosphonate [GMP(CH2)P] (1 mM), a GDP analog resistant to hydrolysis, results in the polymerization of 20-30% of the total tubulin present. Analogous incubations with GDP (1 mM) do not result in tubulin polymerization. Polymeriza...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Sandoval, I V, Jameson, J L, Niedel, J, MacDonald, E, Cuatrecasas, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1978
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392737/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/277919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.7.3178
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