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Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro DNA synthesis on irradiated templates

The effect of UV irradiation on the extent and fidelity of DNA synthesis in vitro was studied by using homopolymers and primed single-stranded ϕX174 phage DNA as substrates. Unfractionated and fractionated cell-free extracts from Escherichia coli pol(+) and polA1 mutants as well as purified DNA poly...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Villani, Giuseppe, Boiteux, Serge, Radman, Miroslav
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1978
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/356043/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.7.3037
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