The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.

Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral sclerosis (ALS). To better understand the contribution of SOD1 mutations in the pathogenesis of familial ALS, we developed transgenic mice expressi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Mourelatos, Z, Gonatas, N K, Stieber, A, Gurney, M E, Dal Canto, M C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39270/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643599/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5472
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!