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TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation
TNF activates three distinct intracellular signaling cascades leading to cell survival, caspase-8–mediated apoptosis, or receptor interacting protein kinase 3 (RIPK3)–dependent necrosis, also called necroptosis. Depending on the cellular context, one of these pathways is activated upon TNF challenge...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926964/ https://ncbi.nlm.nih.gov/pubmed/24535827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201305070 |
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