SEQUENCE-DERIVED STRUCTURAL FEATURES DRIVING PROTEOLYTIC PROCESSING

Proteolytic signaling, or regulated proteolysis, is an essential part of many important pathways such as Notch, Wnt, and Hedgehog. How the structure of the cleaved substrate regions influences the efficacy of proteolytic processing remains underexplored. Here, we analyzed the relative importance in...

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Detalhes bibliográficos
Main Authors: Belushkin, Alexander A., Vinogradov, Dmitry V., Gelfand, Mikhail S., Osterman, Andrei L., Cieplak, Piotr, Kazanov, Marat D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926948/
https://ncbi.nlm.nih.gov/pubmed/24227478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201300416
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