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Vorinostat in Combination with Bortezomib in Patients with Advanced Malignancies Directly Alters Transcription of Target Genes
INTRODUCTION: Vorinostat is a small molecule inhibitor of class I and II histone deacetylase (HDAC) enzymes which alters expression of target genes including the cell cycle gene p21, leading to cell cycle arrest and apoptosis. METHODS: Patients enrolled in a phase I trial were treated with vorinosta...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926898/ https://ncbi.nlm.nih.gov/pubmed/23903894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2242-6 |
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