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MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines

Background Several molecularly-targeted agents are being evaluated in gastric cancer cell lines. In this study we evaluated the synergistic potential of MK-2206, an oral potent allosteric Akt inhibitor, in combination with chemotherapeutic agents in human gastric cancer cell lines. Materials and Met...

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Detalhes bibliográficos
Main Authors: Almhanna, Khaldoun, Cubitt, Christopher L, Zhang, Shumin, Kazim, Sabiha, Husain, Kazim, Sullivan, Dan, Sebti, Said, Malafa, Mokenge
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926890/
https://ncbi.nlm.nih.gov/pubmed/23917345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.25939
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