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Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12

BACKGROUND: Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2 diabetes. RESULTS: PA induced cell death in a dose dependent manner up to 1.5 ...

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Detalhes bibliográficos
Main Authors: Cheon, Hyae Gyeong, Cho, Young Sik
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926261/
https://ncbi.nlm.nih.gov/pubmed/24521082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-21-13
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