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Recursive genomewide recombination and sequencing reveals a key refinement step in the evolution of a metabolic innovation in Escherichia coli

Evolutionary innovations often arise from complex genetic and ecological interactions, which can make it challenging to understand retrospectively how a novel trait arose. In a long-term experiment, Escherichia coli gained the ability to use abundant citrate (Cit(+)) in the growth medium after ∼31,5...

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Bibliografiske detaljer
Main Authors: Quandt, Erik M., Deatherage, Daniel E., Ellington, Andrew D., Georgiou, George, Barrick, Jeffrey E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926077/
https://ncbi.nlm.nih.gov/pubmed/24379390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314561111
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