Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism

Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardiac muscle contraction. Defects in the cardiac isoform, cMyBP-C, cause heart disease. cMyBP-C includes 11 Ig- and fibronectin-like domains and a cMyBP-C-specific motif. In vitro studie...

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Hlavní autoři: Mun, Ji Young, Previs, Michael J., Yu, Hope Y., Gulick, James, Tobacman, Larry S., Beck Previs, Samantha, Robbins, Jeffrey, Warshaw, David M., Craig, Roger
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926057/
https://ncbi.nlm.nih.gov/pubmed/24477690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316001111
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