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X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals

Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kuzmanic, Antonija, Pannu, Navraj S., Zagrovic, Bojan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926004/
https://ncbi.nlm.nih.gov/pubmed/24504120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4220
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