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X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals
Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the e...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926004/ https://ncbi.nlm.nih.gov/pubmed/24504120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4220 |
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