The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses

Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a costimulatory receptor transducing a potent inhibitory signal. Increasing evidence showed that CTLA-4 gene is an important susceptibility locus for autoimmune disorders. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whe...

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Detalhes bibliográficos
Main Authors: Simone, Rita, Pesce, Giampaola, Antola, Princey, Rumbullaku, Margarita, Bagnasco, Marcello, Bizzaro, Nicola, Saverino, Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925529/
https://ncbi.nlm.nih.gov/pubmed/24605322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/215763
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